Don Sebastian

(Reuters) - The U.S. patent office has rejected a patent application from Amarin Corp Plc for its key experimental heart drug.

(Reuters) - Chip-design software maker Synopsys Inc posted a quarterly profit that beat analysts' estimates, helped by strong demand for its new products, and raised its full-year outlook.

(Reuters) - Four Seasons Health Care is not trying to sell itself, as media reports suggested, but is in talks to renegotiate debt and raise new equity, a spokeswoman for Britain's biggest care home operator told Reuters.

(Reuters) - Satellite firm Inmarsat said LightSquared, a venture struggling to build a U.S. mobile broadband service with Inmarsat's spectrum, failed to pay a $56.25 million installment to the British company.

(Reuters) - Chip-equipment maker Applied Materials expects a strong recovery in the second quarter, as orders pick up in an industry beset by a year-long slump.

(Reuters) - LyondellBasell Industries NV's <LYB.N> quarterly operating profit fell far short of Wall Street expectations as refining margins dropped, pushing its stock down 8 percent in premarket trading.

(Reuters) - Chemical maker LyondellBasell Industries NV's <LYB.N> quarterly operating profit fell far short of Wall Street's expectations as refining margins dropped and customers conserved cash.

(Reuters) - Health regulators said ulcer drugs such as AstraZeneca Plc's blockbuster Nexium could increase the risk of clostridium difficile-associated diarrhea (CDAD).

(Reuters) - Shares of Avid Technology Inc jumped 25 percent to a six-month high after the maker of digital audio and video editing products reported a quarterly profit for the first time in four years.

(Reuters) - D.R. Horton Inc <DHI.N>, the top U.S. homebuilder, posted a first-quarter profit, helped by a surge in orders indicating a stabilizing housing market.

(Reuters) - D.R. Horton Inc <DHI.N>, the top U.S. homebuilder, posted a first-quarter profit that beat market expectations, helped by a surge in orders indicating a stabilizing housing market, and said it was looking at spring selling season with "cautious optimism."

(Reuters) - Shares of Google Inc fell 8 percent after the Internet giant's quarterly earnings missed estimates as money paid by marketers for its search ads fell for the first time in two years.

(Reuters) - Shares of Google Inc fell 8 percent after the Internet giant posted a rare quarterly earnings miss and said money paid by marketers for its search ads decreased for the first time in two years.

(Reuters) - U.S. health regulators have approved an expanded label for Merck & Co's treatment for HIV for use with other antiretroviral drugs in children and adolescents.

(Reuters) - Chipmaker Qualcomm Inc <QCOM.O> said founder Irwin Jacobs will retire from the board at the 2012 annual stockholder meeting.

(Reuters) - NDS Group Holdings Ltd, which provides software services to pay television, filed with U.S. regulators to raise up to $100 million in an initial public offering of its common stock.

(Reuters) - NDS Group Holdings Ltd, which provides a unit of News Corp in 1992. It was listed on Nasdaq in software services to pay television, filed with U.S. regulators to raise up to $100 million in an initial public offering of its common stock.

(Reuters) - Biopharmaceutical company Amarin Corp said U.S. health regulators have accepted the marketing application for its heart pill and set an eight-month review period.

(Reuters) - Biopharmaceutical company Amarin Corp said U.S. health regulators have accepted the marketing application for its heart pill AMR101 and set an eight-month review period.

(Reuters) - Apparel maker Perry Ellis International Inc <PERY.O> posted lower third-quarter earnings, lagging market estimates for the first time in at least two years, and said it expects increased promotions to hurt the current quarter as well.